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Le modafinil, lorsqu'il est utilisГ© seul et Г  la posologie recommandГ©e, semble ГЄtre sans danger. Il est gГ©nГ©ralement pris pour rГ©duire les effets de la somnolence et amГ©liore la vigilance. Dans une Г©tude en double aveugle rГ©alisГ©e avec le modafinil, les rГ©ponses physiologiques semblaient ГЄtre cohГ©rentes avec celles d'autres agents stimulants, bien que le modafinil n'ait pas Г©tГ© aussi stimulant que l'amphГ©tamine ou le mГ©thylphГ©nidate.

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La dГ©couverte du modafinil a Г©tГ© rapportГ©e lors de la 173e rГ©union nationale de l'American Chemical Society en mai 1970. C'est un dГ©rivГ© du composГ© adrafinil (2-amino-4,5,6,7-tГ©trahydrobenzothiazole). Certains Г‰tats et gouvernements locaux ont adoptГ© des lois permettant aux mГ©decins de prescrire Modafinil Г  ces fins. Le modafinil est facilement absorbГ© aprГЁs administration orale et les concentrations plasmatiques maximales sont atteintes en 1 Г  2 heures. Il a Г©tГ© dГ©montrГ© que le modafinil augmente l'Г©veil pendant la journГ©e en inhibant les neurones Г  hypocrГ©tine (orexine), qui sont responsables de la promotion et de la suppression du sommeil.

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On ne sait pas si l'utilisation de Modafinil pendant la grossesse est sans danger. Une revue sur l'usage mГ©dical du modafinil publiГ©e dans Annales de mГ©decine interne en 2018 a conclu que mГЄme si les preuves Г©taient limitГ©es, il existait des preuves que le modafinil Г©tait sГ»r et efficace chez les personnes atteintes de TDAH. Le modafinil est un mГ©dicament d'ordonnance utilisГ© pour traiter de nombreux troubles du sommeil, les troubles du sommeil liГ©s au travail postГ© et la suspicion de narcolepsie.

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Cependant, la dose peut varier en fonction d'un certain nombre de facteurs tels que les besoins individuels. Une dose initiale typique chez les personnes atteintes de narcolepsie est de 200 mg, rГ©partie deux fois par jour, qui est augmentГ©e en fonction de la rГ©ponse clinique. Deux effets principaux sont attribuГ©s Г  la dopamine, qui est un neurotransmetteur et un neuromodulateur, et des Г©tudes rГ©alisГ©es sur des animaux suggГЁrent que la dopamine peut agir comme un agent favorisant l'Г©veil et rГ©duire la somnolence.

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Il est souvent vendu comme provigil. Les deux sont utilisГ©s pour traiter la somnolence due Г  la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. La marque de modafinil la plus rГ©pandue est Provigil.

modiodal

Cet effet est principalement excitateur et responsable de l'effet favorisant l'Г©veil du Modafinil. Le modafinil sur ordonnance a Г©galement Г©tГ© approuvГ© par le National Health Service du Royaume-Uni en 2017. La premiГЁre Г©tude utilisant le modafinil a Г©tГ© rГ©alisГ©e par Jouvet et ses collГЁgues dans une expГ©rience sur des rongeurs.

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